Why does the embryo not implant? – Understanding implantation failure
You have already had one or more IVF/ICSI attempts, but the embryos have not implanted? That is frustrating – but there are options for a work-up.
What is implantation failure?
When no pregnancy occurs after at least three transfers with good-quality embryos, this is referred to as recurrent implantation failure (RIF).
Possible causes
- Endometrial factors: the endometrium is not optimally prepared.
- Immunological factors: including an elevated concentration of plasma cells in the endometrium.
- Coagulation disorders: can impair blood flow to the endometrium.
- Embryonic factors: chromosomal abnormalities.
What we can do
- ERA test: determines the optimal window for the transfer.
- Plasma cell diagnostics: detects chronic endometritis.
- Coagulation diagnostics: thrombophilia screening.
- Hysteroscopy: rules out polyps, septa or fibroids.
Our experience
Many patients become successfully pregnant after targeted work-up and adjusted therapy. Do not give up.