The overproduction of male hormones, hyperandrogenaemia, can also affect the sensitive hormonal interaction of the female menstrual cycle. Male hormones are produced at several locations in the female body: if there is a metabolic defect in the region of the adrenal glands, then this can be treated with cortisone. A very common cause of hyperandrogenaemia (increased peripheral effects of normal androgen levels, such as hair growth in areas uncommon for women, acne) is increased body weight. In fatty tissue, oestrogen is used to produce androgen (male hormone) which, together with insulin, inhibits cyclical processes. It is therefore advisable to reduce body weight (diet, exercise) in addition to taking Metformin
This is often coupled with PCOS (Polycystic Ovary Syndrome) which can intensify the symptoms. This causes the increased production of male hormones, especially in the ovaries.
Therapy: In the case of adrenal cortex disorders, the administration of cortisone can be used as a targeted attempt to reduce androgen levels. However, in most cases, ovarian stimulation using Clomifene or Letrozole tablets (off-label!) is necessary to trigger ovulation. Occasionally, a change of therapy to FSH injections may be necessary. In especially persistent cases, a procedure known as ovarian drilling to reduce androgen-producing cells in the ovarian surface via laparoscopy can offer an alternative.