(Frequency approx. 30-40% of the purely female causes of sterility)
The harmonious functioning of the sensitive hormonal interaction between the diencephalon, pituitary gland and the ovaries is essential for a complication-free ovarian cycle. Under optimal conditions, a mature egg is produced in each cycle during the fertile phase of women between 15 and 40 years of age, and more irregularly beyond that age (up to 45 years). In principle, this egg is ready to be fertilised after ovulation. The hypothalamus acts as the superordinate component controlling the release of sex hormones such as FSH (follicle stimulating hormone), responsible for follicular maturation, and LH (luteinizing hormone), which triggers ovulation.
The perfect interplay between these hormones is influenced by other hormones, for example, prolactin, thyroid hormones, male hormones, and insulin. Variations occurring within this system can hinder correct follicular development.
External factors affecting this hormonal interaction, such as competitive sports, significant psychological stress, being over/underweight, drug, nicotine and alcohol abuse can also cause sterility.
Hormonal disorders do not only have a negative effect on the ability to fall pregnant, but they can also cause miscarriage and have a negative influence on child development.